I myself recommend Bearded Dragons...they are large, friendly, and love human contact as well as being incredibly intelligent...as intelligent as the average housecat or toddler at least!  And you can walk them on leashes (look online for bearded dragon leashes or harnesses) and are an overall great lizard to have.  When they are full size, they can be between 1-2 feet from nose to tail!   Read more at http://www.beardeddragon.org/articles/caresheet/

Looking in your profile, I see you already have one!   Well if you want something different, I highly recommend Chinese Water Dragons, they are beautiful and fascinating to watch, or if you want one you can more pick up, perhaps a large iguana.    I myself really WANT a Parson's Chameleon...they are so big and wonderful...and stunning!  So if you already have a beardie, my second suggestion is a Parson's Chameleon!

Hmmmm my first question would be why do you want a large lizard?, my second questions would be to you have the proper accomodations to house a large lizard? Monitor Lizards get large but my gut feeling talls me that you are looking for something more beginner and thats not the way to go. do you have any experience with lizards? If so what kinds?

well I should have checked your page before I posted, In time my friend that savanna will be large enough and with the proper care and handling it will be just what you are looking for 

T-Rex.

What do you consider large?  I think leachies are pretty awesome large geckos, but they are expensive.  Savannah monitors require a large living area, but I have heard their temperment is really good as long as you work with them, same with Argentine Tegus.  Really large but good temperment would be a water monitor, but you need a massive enclosure and a lot of experience.  Iguanas can be good, but they do also require massive enclosures.

Velociraptor.

get a nile monitor 

How about an alligator? 

where do you live?

for example, in WA, Water Monitors are illegal (although Niles are not, go figure) as are crocodilians. do you have any restrictions where you live?

I  have been talking to people about Caiman Lizards(Dracaena guianensis) that have just started popping up in the pet trade around my area. They get very large, about the size of a large tegu, and can have pretty docile temprements. That and they get some spectacular colors.

If you consider a B&W tegu make sure it is argentinian not columbian. You could also consider Blue tongue skinks, some get pretty big. Black Throats get big but start with a baby or a very young one. Housing is the most important part. Have a big cage BEFORE you get a big lizard.

I have a Colombian Tegu that is absolutely delightful - he's sweet, VERY intelligent, sociable, and is target trained - - - that being said, it's the exception to the rule. With any large lizard, tegus included, you have to spend countless hours working with them in order to harness a "mild temperament" - my Colombian is absolutely beautiful, and his size is more manageable than that of one of the larger Argentines. I've only met evil caiman lizards, but that could just be my luck. I agree with earlier sentiments though - gotta get a baby and work with it a LOT. Taming down Tinkerbell was not easy - and it took a long time - but I've never been bitten or even "swung" at, and it's totally worth it. I adore him to pieces <3    ...I'm sure your sav didn't come "mild mannered", haha. 

(Tinkerbell is the handsome man in my avatar photo, in case that wasn't blatantly obvious)

I vote tegu, go for blues!

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what about a Argentine Black and White Tegu? they live 15+ years and can learn some tricks and answer to there name, they grow to 4 1/2 feet. Like most lizards as long as you treat em right you even can get them use to a harness for a walk. (but I  think that would freak out nabours)

+ 1 for argentine tegu.  bottom line is to make it the one you like to watch the most.

an argentine tegu or an iguana seems suitable, but don't get those or a chameleon without the right experience