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Q: Correct Amikacin dose for my snake?
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My baby retic (130 grams) has an RI and mouth rot. The vet prescribed me Amikacin today with a schedule of injecting .06 ml every 24 hours for 7 days. Online most things recommend dosing only every 72 hours. Is this dose safe or correct? I have no idea how the dilutions and dosing works for antibiotics and I’m afraid it will kill my snake if I give it to her like this. Is the daily amount correct as well? Any help from people who have used Amikacin or vets would be greatly appreciated

Points: 250
Topics: General Health , Respiratory , Mouth
Tags: Antibiotics, Infection, Medicine, Respiratory, Ri, Sicksnake
Species: Pythons > Pythons > Python reticulatus reticulatus
Administrative: Show/Hide

Member Comment 1/4/2018 9:41:08 PM

I’ve used enrofloxacin (Baytril) for turtles and ceftazidime (Fortaz) for snakes, never Amikacin though. http://www.anapsid.org/resources/rxdose.html Is a great resource for reptile medicine, says it’s aimilar to Baytril and is nephrotoxic so is typically given with subq fluids. I’ve used Baytril before though, without subq, and it has been succsssful. You’ll have to tell me the concentration of Amikacin to calculate the dosage but 0.06 mL sounds comparable so what I’ve given with Baytril. Personally, I prefer Fortaz, but is is newer and more expensive so not all vets use it. Just for reference, I am not a veterinarian. However, I do work pretty extensively with a local turtle rehabilitation laboratory and do have some medical and rehab experience.
Author Comment 1/13/2018 5:30:41 PM

10.4mg/ml is the doseage. I’ve followed vet instructions and just finished up her treatment. It seemed to help a lot, she’s not gurgling anymore, significantly less mucus and her mouth rot is even almost gone, no more sneezing and crackling in her lungs. However, I finished her treatment and she still has a slight click when she breaths if I hold her head by my ear, and her neck is clicking (only like 2 inches down from her head) so I’m not sure if the treatment killed all the bacteria and she just has leftover mucus she still needs to expel, or if she’s just downgraded to a mild URI and still needs further treatment. I’m trying to soak her daily to help her loosen up any remaining mucus in her trachea but I’m worried she might relapse on me. I wish I’d been given enough for a follow up dose. Have you noticed if your snakes had any mild clicking/mucus left after you treated them?
Member Comment 1/17/2018 4:18:15 PM

Serpents of Oz

Your vet prescribed Amikacin doseage at about 5mg/kg of body weight, which is also usually what is prescribed for Baytril in reptiles.

5 mg amikacin/per kg body weight multiplied by 0.130 Kg (the weight of your snake in kilos) equals 0.65mg amikacin which is the dose, then to get that amount of amikacin in solution to inject, divide by 10.4 mg per ml (the concentration of amikacin in the solution) and you get 0.0625 ml per injection, essentially what your vet prescribed.  Hope this was helpful.  

I would recomend a follow up visit to the vet.  Also keep the ambient cage temp in the lower 80's with a localized basking site in the upper 80's left on 24/7 until the animal recovers, and avoid extremes of humidity, not below 55% and not higher than 70%, and disinfect water bowl daily and replace with fresh water, as gram negative bacteria thrive in standing water. I would also offer small meals at least once a week so the animal has the nutrients it needs to recover.

Best of wishes for you and your retic, 


Member Comment 1/17/2018 4:30:35 PM

Serpents of Oz
Not sure why the font size is bigger towards the end, it was not intended.
Member Comment 1/17/2018 4:42:28 PM

Serpents of Oz

Oh, and typically Amikacin is given every 2nd or 3rd day along with fluids, such as lactated ringers solution to mitigate the nephrotoxic effects of this antibiotic.

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